The blood/cerebrospinal fluid partitioning of pyrazinamide: a study during the course of treatment of tuberculous meningitis.
نویسندگان
چکیده
Concentrations of pyrazinamide were measured in serum and cerebrospinal fluid (CSF) of 17 adult patients with tuberculous meningitis up to six months after starting treatment. Pyrazinamide penetrated excellently into the CSF and mean concentrations at various intervals up to six months of treatment were consistently above that required for inhibition of the growth of Mycobacterium tuberculosis. The blood/CSF partitioning of pyrazinamide does not change as the patients recover from the meningitis.
منابع مشابه
SHORT-COURSE THERAPY IN TUBERCULOUS MENINGITIS. A STUDY OF 16 PATIENTS
From 1986-1989, sixteen patients suffering from TB meningitis aged 12-58, with CSF smear or culture positive for Mycobacterium tuberculosis were hospitalized and treated with rifampin (RIF) , isoniazid (INH) , pyrazinamide (PZA) and ethambutol (ETB) for nine months. In all patients, ETB and PZA were withdrawn after three months and INH and RIF were continued for the next six months. 81.2 p...
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Background and Aim: Diagnosis of tuberculous meningitis is difficult because of its non-specific clinical presentations which may be confused with other disorders of central nervous system. The initiation of anti-TB medication can often be delayed because of lack of available laboratory tests. This study was aimed at evaluating the adenosine deaminase (ADA) concentration in differentiating tube...
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BACKGROUND Among the various forms of TB, tuberculous meningitis (TBM) is the most severe, with about 30% mortality and 50% of survivors left with neurological sequelae. Children suffer more frequently from TBM than adults and outcomes are often poor due to difficulties in making the diagnosis and uncertainty regarding the best anti-tuberculosis drug regimen. The aim of this prospective study w...
متن کاملEstimation of Lactate Dehydrogenase Activity in cerebrospinal fluid in different types of meningitis
Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein...
متن کاملEstimation of Lactate Dehydrogenase Activity in cerebrospinal fluid in different types of meningitis
Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein...
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عنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 53 1 شماره
صفحات -
تاریخ انتشار 1990